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By Professor Dr. Erich Gebhart, Professor Dr. Ruben M. Arutyunyan (auth.)

Anticlastogens in Mammalian and Human Cells covers learn at the safeguard of chromosomes from the motion of chemical mutagens by means of use of common and artificial antimutagens, which, due to their particular motion on clastogenic harm are known as anticlastogens. in response to an introductory bankruptcy on nature and mode of formation of chromosome aberrations triggered by means of chemical and in addition actual mutagens, the motion of anticlastogens is mentioned intimately. A definition and delineation of the time period anticlastogenesis is by way of issues at the a variety of chances of classifying anticlastogens. recognition is paid to the motion of anticlastogens in mammalian and human phone tradition platforms, in vivo info on anticlastogens are provided in nice aspect, as are the activities of anticlastogens on precipitated sister chromatid exchanges in quite a few try out structures. A often historic side-glance on the motion of anticlastogens on chromosome harm triggered by means of ionizing radiation is taken. the sensible outcomes of the findings on anticlastogenic motion are broadly mentioned as features of additional research.

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Extra resources for Anticlastogens in Mammalian and Human Cells

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The unstimulated lymphocytes, which were naturally" synchronized" at the 00 stage of the cell cycle, are an ideal target for treatment by mutagenic agents of noncycling cells, providing a more concrete interpretation of results, if one is interested in analyzing the influence of repair systems. For the research on mechanisms of modification, this possibility is invaluable. , before cell division, also has its advantages. In the studies of Wolff and Arutyunyan (1979), it was shown that the alkylating agent thio-TEPA can induce aberrations in G2 cells, thus confirming the previous data of Chebotarev and Yakovenko (1974).

Only combined examinations of all mentioned endpoints in the different groups at risk can yield a real basis for a possible preferential selection. There are some possibilities to study the action of chemical mutagens on somatic cells in real situations. A quantitative approach can be used to estimate the interaction effects of chemical mutagens (Bochkov et al. 1979), and for comparative investigations on mutagenic actions in vivo and in vitro (Bochkov et al. 1986) The latter report presents data on a linear increase in SCE and an exponential increase in chromosomal aberration rates with an increased cyclophosphamide dose in human lymphocytes in vivo and in vitro.

This was found particularly with several antioxidants which due to their potential as redox systems" either accept or donate electrons, which may alternatively render them either protective or noxious" (de Flora and Ramel 1988 after Stich et al. 1984). According to our knowledge on the formation of mutagenic nitrosamines from nitrates and tertiary amines (Sen et al. 1969), the reaction products of antimutagens and mutagens, if formed at all, in principle could also act detrimentally. De Flora and Ramel (1988) referred to findings, which showed for instance that the reaction products of thiols and MNNG are inactive in an extracellular environment, while they methylate DNA when generated within the cell.

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