Download Applications of Toxicogenomic Technologies to Predictive by National Research Council, Division on Earth and Life PDF

By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

The hot box of toxicogenomics provides a almost certainly strong set of instruments to raised comprehend the health and wellbeing results of exposures to toxicants within the surroundings. on the request of the nationwide Institute of Environmental wellbeing and fitness Sciences, the nationwide study Council assembled a committee to spot the advantages of toxicogenomics, the demanding situations to attaining them, and capability ways to overcoming such demanding situations. The file concludes that knowing the opportunity of toxicogenomics to enhance public well-being judgements would require a concerted attempt to generate info, utilize current info, and learn info in new ways--an attempt requiring investment, interagency coordination, and information administration concepts.

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These compounds included acetaminophen, amiodarone, aflatoxin B1, carbon tetrachloride, coumarin, hydrazine, 1,2-dichlorobenzene, and 18 others. The aim was to determine whether biologic samples from rats treated with these various compounds can be classified based on gene expression profiles. Hepatic gene expression profiles were analyzed using a supervised learning method (support vector machines [SVM]) to generate classification rules and combine this with recursive feature elimination to identify a compact set of probe sets with potential use as biomarkers.

Paucity of data on the impact of human variability on susceptibility, including age, gender, race, disease, and other confounders. Overview of Toxicogenomic Technologies Toxicogenomic technologies comprise several different technology platforms for analysis of genomes, transcripts, proteins, and metabolites. These technologies are described briefly here and in more detail in Chapter 2. It is important to recognize two additional issues associated with the use of toxicogenomic technologies. First, the large quantity of information that a single experiment can generate, and the comprehensive nature of this information, is much greater than what traditional experiments generate.

In short, toxicogenomic technologies should be used to investigate how exposure during early development conveys susceptibility to drug and chemical toxicities. Mixtures Although much toxicology focuses on the study of single chemicals, humans are frequently exposed to multiple chemicals. It is difficult to decipher how exposure to many chemicals will influence the effects of each one. It is unlikely that toxicogenomic signatures will be able to decipher all interactions among complex mixtures, but it should be possible to use mechanism-of-action data to design informative toxicogenomic experiments, including screening chemicals for potential points of biologic conversion (overlap) such as shared activation and detoxification pathways, enhancing identification and exploration of potential interactions, and moving beyond empirical experiments.

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